After fighting his demons for decades, John Rambo now lives in peace on his family ranch in Arizona, but his rest is interrupted when Gabriela, the granddaughter of his housekeeper María, disappears after crossing the border into Mexico to meet her biological father. Rambo, who has become a true father figure for Gabriela over the years, undertakes a desperate and dangerous journey to find her.
When governments fail to act on behalf of captive missionaries, ex-Green Beret John James Rambo sets aside his peaceful existence along the Salween River in a war-torn region of Thailand to take action. Although he's still haunted by violent memories of his time as a U.S. soldier during the Vietnam War, Rambo can hardly turn his back on the aid workers who so desperately need his help.
Combat has taken its toll on Rambo, but he's finally begun to find inner peace in a monastery. When Rambo's friend and mentor Col. Trautman asks for his help on a top secret mission to Afghanistan, Rambo declines but must reconsider when Trautman is captured.
John Rambo is released from prison by the government for a top-secret covert mission to the last place on Earth he'd want to return - the jungles of Vietnam.